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The Landscape of L1 Retrotransposons in the Human Genome Is Shaped by Pre-insertion Sequence Biases and Post-insertion Selection.

Sultana T, van Essen D, Siol O, Bailly-Bechet M, Philippe C, Zine El Aabidine A, Pioger L, Nigumann P, Saccani S, Andrau JC, Gilbert N, Cristofari G.

Mol Cell. 2019 / vol 74(3) / pages 555-570

Histone H3K9 Methyltransferase G9a in Oocytes Is Essential for Preimplantation Development but Dispensable for CG Methylation Protection.

Au Yeung WK, Brind'Amour J, Hatano Y, Yamagata K, Feil R, Lorincz MC, Tachibana M, Shinkai Y, Sasaki H.

Cell Rep 2019 / vol 27(1) / pages 282-293.e4

Mineralocorticoid Receptor Antagonism Limits Experimental Choroidal Neovascularization and Structural Changes Associated With Neovascular Age-Related Macular Degeneration

Min Zhao 1 2 3 , Irmela Mantel 4 , Emmanuelle Gelize 1 2 3 , Xinxin Li 1 2 3 , Xiaoyue Xie 1 2 3 , Alejandro Arboleda 1 2 3 5 , Marie Seminel 1 2 3 , Rinath Levy-Boukris 1 2 3 , Marilyn Dernigoghossian 1 2 3 , Andrea Prunotto 6 , Charlotte Andrieu-Soler 7 , Carlo Rivolta 6 8 , Jérémie Canonica 4 , Marie-Christine Naud 1 2 3 , Sebastian Lechner 2 3 9 , Nicolette Farman 2 3 9 , Irene Bravo-Osuna 10 11 12 , Rocio Herrero-Vanrell 10 11 12 , Frederic Jaisser 2 3 9 , Francine Behar-Cohen 13 14 15 16

Nat Commun 2019 / vol 10 (1) / pages 369

[Rheumatology, the Multitude of Options]

Jacques Morel 1 , Denis Mulleman 2

Med Sci (Paris) 2019 / vol 35 (12) / pages 1029-1033

[Monoclonal Antibodies in Infectious Diseases: New Partners in the Therapeutic Arsenal]

Guillaume Desoubeaux 1 , Mireia Pelegrin 2

Med Sci (Paris) Dec 2019 / vol 35 (12) / pages 1008-1013

Probing transcription factor combinatorics in different promoter classes and in enhancers.

Vandel J., Cassan O., Lebre S., Lecellier CH*, Brehelin L*.

BMC Genomics 2019 / vol 20(1) / pages 103

Genomic Imprinting and Physiological Processes in Mammals.

Tucci V, Bartolomei MS, Benvenisty N, Bourc'his D, Charalambous M, Dulac C, Erice Imprinting Group : Feil R, Glaser J, Huelsmann L, John RM, McNamara GI, Moorwood K, Muscatelli F, Sasaki H, Strassmann BI, Vincenz C, Wilkins J, Isles AR, Kelsey G, Ferguson-Smith AC.

Cell 2019 / vol 176(5) / pages 952-965

Microscopy-Based Chromosome Conformation Capture Enables Simultaneous Visualization of Genome Organization and Transcription in Intact Organisms.

Cardozo Gizzi AM, Cattoni DI, Fiche JB, Espinola SM, Gurgo J, Messina O, Houbron C, Ogiyama Y, Papadopoulos GL, Cavalli G, Lagha M, Nollmann M.

Mol Cell. 2019 / vol pii: S1097-2765(19)30011-5

Probing transcription factor combinatorics in different promoter classes and in enhancers.

Vandel J, Cassan O, Lèbre S, Lecellier CH*, Bréhélin L*.

BMC Genomics. 2019 / vol 20(1) / pages 103

Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing.

Vautrin A, Manchon L, Garcel A, Campos N, Lapasset L, Laaref AM, Bruno R, Gislard M, Dubois E, Scherrer D, Ehrlich JH, Tazi J.

Sci Rep. 2019 / vol 9(1) / pages 792

Safety, tolerability and impact on viral reservoirs of the addition to antiretroviral therapy of ABX464, an investigational antiviral drug, in individuals living with HIV-1: a Phase IIa randomised controlled study.

Rutsaert S, Steens JM, Gineste P, Cole B, Kint S, Barrett PN, Tazi J, Scherrer D, Ehrlich HJ, Vandekerckhove L

J Virus Erad. 2019 / vol 5(1) / pages 10-22.

Non-Cell Cycle Functions of the CDK Network in Ciliogenesis: Recycling the Cell Cycle Oscillator

Krasinska L, Fisher D.

Bioessays 2018 / vol 40 / pages e1800016

The E3 Ubiquitin Ligases TRIM17 and TRIM41 Modulate α-Synuclein Expression by Regulating ZSCAN21.

Lassot I, Mora S, Lesage S, Zieba BA, Coque E, Condroyer C, Bossowski JP, Mojsa B, Marelli C, Soulet C, Tesson C, Carballo-Carbajal I, Laguna A, Mangone G, Vila M, Brice A, Desagher S.

Cell Rep 2018 / vol 25(9) / pages 2484-2496

Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs.

Dufourt J, Trullo A, Hunter J, Fernandez C, Lazaro J, Dejean M, Morales L, Nait-Amer S, Schulz KN, Harrison MM, Favard C, Radulescu O, Lagha M.

Nat Commun 2018 / vol 9(1) / pages 5194

Remembering the past: Mitotic bookmarking in a developing embryo.

Bellec M, Radulescu O, Lagha M.

Curr Opin Syst Biol 2018 / vol 11 / pages 41-49

Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair

Kallimasioti-Pazi EM1, Thelakkad Chathoth K1, Taylor GC1, Meynert A1, Ballinger T1, Kelder MJE1, Lalevée S2, Sanli I2, Feil R2, Wood AJ1

PLos Biol 2018 / vol 16(12) / pages e2005595

Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection.

Valle-Casuso JC, Angin M, Volant S, Passaes C, Monceaux V, Mikhailova A, Bourdic K, Avettand-Fenoel V, Boufassa F, Sitbon M, Lambotte O, Thoulouze MI, Müller-Trutwin M, Chomont N, Sáez-Cirión A.

Cell Metab 2019 / vol 29(3) / pages 611-626.e5

Thymoquinone Potently Enhances the Activities of Classically Activated Macrophages Pulsed with Necrotic Jurkat Cell Lysates and the Production of Antitumor Th1-/M1-Related Cytokines.

Miliani M, Nouar M, Paris O, Lefranc G, Mennechet F, Aribi M.

J Interferon Cytokine Res. 2018 / vol 38 (12)

SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States.

Cossec JC, Theurillat I, Chica C, Búa Aguín S, Gaume X, Andrieux A, Iturbide A, Jouvion G, Li H, Bossis G, Seeler JS, Torres-Padilla ME, Dejean A.

Cell Stem Cell 2018 / vol 23 (5) / pages 742-757

SOX9 has distinct regulatory roles in alternative splicing and transcription.

Girardot M, Bayet E, Maurin J, Fort P, Roux P, Raynaud P.

Nucleic Acids Res 2018 / vol 2018 / pages 9106-9118

Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons.

Bayó-Puxan N, Terrasso AP, Creyssels S, Simão D, Begon-Pescia C, Lavigne M, Salinas S, Bernex F, Bosch A, Kalatzis V, Levade T, Cuervo AM, Lory P, Consiglio A, Brito C, Kremer E.

Sci Rep 2018 / vol 8(1) / pages 16644

Thalamocortical and corticothalamic pathways differentially contribute to goal-directed behaviors in the rat.

Alcaraz F, Fresno V, Marchand AR, Kremer EJ, Coutureau E, Wolff M.

Elife 2018 / vol 7 / pages e32517

MRTFA augments megakaryocyte maturation by enhancing the SRF regulatory axis.

Rahman NT, Schulz VP, Wang L, Gallagher PG, Denisenko O, Gualdrini F, Esnault C, Krause DS.

Blood Adv. 2018 / vol 2(20) / pages 2018

TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1.

Lionnard L, Duc P, Brennan MS, Kueh AJ, Pal M, Guardia F, Mojsa B, Damiano MA, Mora S, Lassot I, Ravichandran R, Cochet C, Aouacheria A, Potts PR, Herold MJ, Desagher S*#, Kucharczak J*#

Cell Death Differ. 2019 / vol 26 / pages 902-917

GNIP1 E3 ubiquitin ligase is a novel player in regulating glycogen metabolism in skeletal muscle.

Montori-Grau M, Pedreira-Casahuga R, Boyer-Díaz Z, Lassot I, García-Martínez C, Orozco A, Cebrià J, Osorio-Conles O, Chacón MR, Vendrell J, Vázquez-Carrera M, Desagher S, Jiménez-Chillarón JC, Gómez-Foix AM

Metabolism 2018 / vol 83 / pages 177-187

Parallels between Mammalian Mechanisms of Monoallelic Gene Expression.

Khamlichi AA, Feil R.

Trends Genet 2018 / pages pii: S0168-9525(18)30137-9

Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing.

Shoaib M1, Walter D1, Gillespie PJ2, Izard F3, Fahrenkrog B4, Lleres D5, Lerdrup M1, Johansen JV1, Hansen K1, Julien E3,6, Blow JJ2, Sørensen CS7.

Nat Commun. 2018 / vol 9(1) / pages 3704

A Growing Toolbox to Image Gene Expression in Single Cells: Sensitive Approaches for Demanding Challenges.

Pichon X. , Lagha M. , Mueller F. , Bertrand E.

Mol Cell 2018 / vol 71(3) / pages 468-480

Exogenous LRRK2G2019S induces parkinsonian-like pathology in a nonhuman primate.

Mestre-Francés N, Serratrice N, Gennetier A, Devau G, Cobo S, Trouche SG, Fontès P, Zussy C, De Deurwaerdere P, Salinas S, Mennechet FJ, Dusonchet J, Schneider BL, Saggio I, Kalatzis V, Luquin-Piudo MR, Verdier JM, Kremer EJ

JCI Insight. 2018 / vol 3(14) / pages pii: 98202

Humoral immune response to adenovirus induce tolerogenic bystander dendritic cells that promote generation of regulatory T cells.

Tran TTP, Eichholz K, Amelio P, Moyer C, Nemerow GR, Perreau M, Mennechet FJD, Kremer EJ

PLoS Pathog. 2018 / vol 14(8) / pages e1007127

Developmental differences between neonatal and adult human erythropoiesis.

Yan H, Hale J, Jaffray J, Li J, Wang Y, Huang Y, An X, Hillyer C, Wang N, Kinet S, Taylor N, Mohandas N, Narla A, Blanc L

Am J Hematol. 2018 / vol 93(4) / pages 494-503

Probabilistic analysis of recurrence plots generated by fractional Gaussian noise

Ramdani S, Bouchara F, Lesne A.

Chaos 2018 / vol 28(8) / pages 085721

Human Enhancers Harboring Specific Sequence Composition, Activity, and Genome Organization Are Linked to the Immune Response.

Lecellier CH*, Wasserman WW, Mathelier A*.

Genetics 2018 / vol 209(4) / pages Genetics. 2018 Aug;209(4):1055-1071. doi: 10.1534/genetics.118.301116.

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells.

Bornstein C, Nevo S, Giladi A, Kadouri N, Pouzolles M, Gerbe F, David E, Machado A, Chuprin A, Toth B, Goldberg O, Itzkovitz S, Taylor N, Jay P, Zimmermann VS, Abramson J, Amit I

Nature. 2018 / vol 559(7715) / pages 622-626

The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones.

Maurizy C., Quinternet M., Abel Y., Verheggen C.,. Santo P E, Bourguet M., Paiva A.C.F., Bragantini B., Chagot M-E., Robert M-C., Abeza C., Fabre P., Fort P., Vandermoere F, Sousa P.M. F., Rain J-C., Charpentier B., Bandeiras T-M., Cianférani S., Pradet-Balade B., Manival X., Bertrand E.

Nat Commun 2018 / vol 9(1) / pages 2093

Environmental effects on chromatin repression at imprinted genes and endogenous retroviruses.

Pathak R. , Feil R.

Curr Opin Chem Biol 2018 / vol 45 / pages 139-147

Human Enhancers Harboring Specific Sequence Composition, Activity, and Genome Organization Are Linked to the Immune Response.

Lecellier, C.H. , Wasserman W.W., Mathelier, A.

Genetics 2018 June 5 / pages pii: genetics.301116.2018.

Neutrophils are essential for induction of vaccine-like effects by antiviral monoclonal antibody immunotherapies.

Naranjo-Gomez M, Lambour J, Piechaczyk M, Pelegrin M.

JCI Insight. 2018 / vol 3(9) / pages pii: 97339

DUOX2-mediated production of reactive oxygen species induces epithelial mesenchymal transition in 5-fluorouracil resistant human colon cancer cells.

Kang KA, Ryu YS, Piao MJ, Shilnikova K, Kang HK, Yi JM, Boulanger M, Paolillo R, Bossis G, Yoon SY, Kim SB & Hyun JW

Redox Biol. 2018 / vol 17 / pages 224-235

Meg3 Non-coding RNA Expression Controls Imprinting by Preventing Transcriptional Upregulation in cis.

Sanli, I.*, Lalevée, S.*, Camissa, M., Perrin, A., Rage, F., Riccio, A., Llères, D., Bertrand, E., Feil, R.

Cell Rep 2018 / vol 23(2) / pages 337-348