Epigenetic transitions in germ cell development and meiosis

Kota, S. K.; Feil, R.

Dev Cell

2010-11-16 / vol 19 / pages 675-86


Germ cell development is controlled by unique gene expression programs and involves epigenetic reprogramming of histone modifications and DNA methylation. The central event is meiosis, during which homologous chromosomes pair and recombine, processes that involve histone alterations. At unpaired regions, chromatin is repressed by meiotic silencing. After meiosis, male germ cells undergo chromatin remodeling, including histone-to-protamine replacement. Male and female germ cells are also differentially marked by parental imprints, which contribute to sex determination in insects and mediate genomic imprinting in mammals. Here, we review epigenetic transitions during gametogenesis and discuss novel insights from animal and human studies.

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S1534-5807(10)00462-4 [pii] 10.1016/j.devcel.2010.10.009

1878-1551 (Electronic) 1534-5807 (Linking)

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