In past years, many efforts were invested to define epigenetic features associated with enhancers of transcription. We propose that both transcription initiation and the H3K4me3 histone modification are among the best hallmarks of active enhancers in several primary tissues and extend the concept of large transcription initiation platforms (TIPs).
Initiating RNA polymerase II and TIPs as hallmarks of enhancer activity and tissue-specificity
Koch, F.; Andrau, J. C.
2011
Transcription
2011-12 / vol 2 / pages 263-8
Abstract
10.4161/trns.2.6.18747
2154-1272 (Electronic) 2154-1272 (Linking)
Tags
Humans; Animals; Histones/metabolism; Enhancer Elements, Genetic/*genetics; Promoter Regions, Genetic/genetics; Protein Binding; Methylation; Lysine/metabolism; Transcription Factors/metabolism; RNA Polymerase II/*metabolism; *Gene Expression Profiling; Transcription, Genetic/*genetics