Pax genes have important roles in the regulation of stem cell behavior, leading to tissue differentiation. In the case of skeletal muscle, Pax3 and Pax7 perform this function both during development and on regeneration in the adult. The myogenic determination gene Myf5 is directly activated by Pax3, leading to the formation of skeletal muscle. Fgfr4 is also a direct Pax3 target and Sprouty1, which encodes an intracellular inhibitor of fibroblast growth factor (FGF) signaling, is under Pax3 control. Orchestration of FGF signaling, through Fgfr4/Sprouty1, modulates the entry of cells into the myogenic program, thus controling the balance between stem cell self-renewal and tissue differentiation. This and other aspects of Pax3/7 function in regulating the behavior of skeletal muscle stem cells are discussed.
Regulation of skeletal muscle stem cell behavior by Pax3 and Pax7
Lagha, M.; Sato, T.; Bajard, L.; Daubas, P.; Esner, M.; Montarras, D.; Relaix, F.; Buckingham, M.
Cold Spring Harb Symp Quant Biol
2008 / vol 73 / pages 307-15
10.1101/sqb.2008.73.006 sqb.2008.73.006 [pii]
1943-4456 (Electronic) 0091-7451 (Linking)
IGMM team(s) involved in this publication
Regulation of gene expression during development
Animals; Cell Proliferation; Mice; Signal Transduction; Models, Biological; Cell Differentiation; Embryonic Stem Cells/cytology/metabolism; Embryonic Development; Paired Box Transcription Factors/genetics/*metabolism; PAX7 Transcription Factor/genetics/*metabolism; Adaptor Proteins, Signal Transducing; Adult Stem Cells/cytology/metabolism; Cell Movement; Cell Survival; Membrane Proteins/genetics/metabolism; Multipotent Stem Cells/cytology/metabolism; Muscle Development; Myoblasts, Skeletal/*cytology/*metabolism; Myogenic Regulatory Factor 5/genetics/metabolism; Phosphoproteins/genetics/metabolism; Receptor, Fibroblast Growth Factor, Type 4/genetics/metabolism; Stem Cells/*cytology/*metabolism