Most second-generation ON antisense analogs do not activate RNase H. Alternative strategies to arrest translation in a reticulocyte cell-free assay programmed by VSV mRNAs have been explored.
Translation arrest by RNase H incompetent antisense oligonucleotides
Robbins, I.; Gee, J. E.; Mitta, G.; Rayner, B.; Vichier-Guerre, S.; Leng, M.; Van der Laan, A.; van Boom, J.; Nelson, J. S.; Lebleu, B.
1999
Nucleosides Nucleotides & Nucleic Acids
1999 / vol 18 / pages 1667-1668
Abstract
0732-8311