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The ability of SAMHD1-deficient monocytes to trigger the Type I IFN response depends on cGAS and mitochondrial DNA

Jesse Rabinowitz 1 , Isabelle K Vila 2 , Charlotte Luchsinger 1 , Cinzia Bertelli 1 , Moritz Schüssler 2 , Clara Taffoni 2 , Bin Cui 1 , Annie Zhi Dai 1 , Mohammad M Rashid 1 , William J Cisneros 3 , Daphne Cornish 3 , Juan Redondo 1 , Kathryn A Jackson-Jones 3 , Lacy M Simons 3 , Ramon Lorenzo-Redondo 3 , Nadine Laguette 2 , Judd F Hultquist 3 , Felipe Diaz-Griffero 4

J Biol Chem .

2025 Aug; / pages 301(8):110430

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10.1016/j.jbc.2025.110430

PMC12312027

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